Small Molecule CDMO Market

Small Molecule CDMO Market Size By Product (Small Molecule Drug Product and Small Molecule API), By Stage Type (Clinical, Commercial, and Preclinical), By Customer Type (Biotechnology and Pharmaceutical), and By Therapeutic Area (Oncology, Neurology, Infectious Disease, Cardiovascular Disease, Respiratory Disorders, Metabolic Disorders, and Others), Regions, Global Industry Analysis, Share, Growth, Trends, and Forecast 2023 to 2032

Base Year: 2022 Historical Data: 2019-21
  • Report ID: TBI-13945
  • Published Date: Jan, 2024
  • Pages: 239
  • Category: Healthcare
  • Format: PDF
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The global small molecule CDMO market was valued at USD 47.8 billion in 2022, growing at a CAGR of 5.8% from 2023 to 2032. The market is expected to reach USD 84.0 billion by 2032. The increased frequency of age-related illnesses and cancer and the expanding need for small molecules are the main factors driving this growth in the pharmaceutical industry's R&D spending. Small compounds are less expensive than biological medications. As a result, rising demand for reasonably priced medications is anticipated to fuel market expansion.

Market Introduction:

Third-party suppliers, CDMOs, provide pharmaceutical companies with outsourced development and manufacturing services. CDMOs are currently a crucial link in the value chain of the pharmaceutical industry, offering professional development and production services in the small molecule manufacturing sector. The increasing prevalence of chronic illnesses drives the demand for novel small-molecule drugs. The pharmaceutical industry's emphasis on creating new, more effective, tailored treatments has led to a demand for creative drug delivery strategies and larger product pipelines. In addition, although they are in charge of more than 70% of the medications in the R&D pipeline, small and mid-sized pharmaceutical businesses sometimes lack the resources to launch their clinical pipeline successfully. An increase in cancer cases and a rise in the need for accurate diagnostics and oncology procedure R&D are driving the growth of the small molecule CDMO market. The World Health Organisation estimates that cancer will be the world's biggest cause of death in 2020, with 10 million deaths due to the disease. Throughout the projection period, a high cancer incidence rate is anticipated to fuel market demand and sustain the need for novel cancer treatments.

Small Molecule CDMO Market Size

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Recent Development

In June 2023, To transform CDMO services, Porton Pharma announced the opening of a cutting-edge Small Molecule Platform in Shanghai. Shanghai's production and research facilities are set up to offer complete solutions for synthetic macromolecules, biological macromolecules, medication formulation, and drug substances. 

In October 2022, To increase its capacity for developing and producing small molecules, Cambrex, a CDMO, stated that it will invest in a new 21,000-square-foot research and development facility in Minneapolis, Minnesota. 

Market Dynamics:

Drivers

Increasing demand- Since small-molecule drugs can effectively treat a wide range of diseases and disorders, there is a growing demand for these drugs. Pharmaceutical companies are drawn to small molecule drugs due to their ease of manufacturing and cheaper cost of goods. The need for small molecule CDMO services has grown, propelling the market’s growth.

Opportunities:

Increasing outsourcing of drug development and manufacturing- In recent years, drug development and manufacturing outsourcing have become more popular due to growing R&D expenses and the demand for specialised knowledge. CDMOs specialising in small-molecule innovation are well-suited to offer these services since they possess the tools, knowledge, and facilities required to assist in creating and producing small-molecule drugs. This is expected to provide growth opportunities for the market during the forecast period.

Regional segmentation analysis:

The regions analyzed for the market include North America, Europe, South America, Asia Pacific, the Middle East, and Africa. Asia Pacific emerged as the largest global small molecule CDMO market, with a 41.2% market revenue share in 2022.

Regional market growth is expected to be driven by low-cost services, low-cost labour costs, and the availability of trained labour at a lower cost than in developed nations. Throughout the projected period, one of the main drivers anticipated to propel regional market expansion is the growing regulatory focus on quality control for manufacturing. Asia Pacific is home to several regulatory bodies, including the Singapore Health Sciences Authority (HSA) in Singapore, the Therapeutic Goods Administration (TGA) in Australia, the Ministry of Food and Drug Safety (MFDS) in South Korea, and the Pharmaceuticals and Medical Devices Agency (PMDA) in Japan. These organisations ensure that the medications made in their respective nations are of the highest calibre. This encourages regional market expansion even more.

Asia Pacific Region Small Molecule CDMO Market Share in 2022 - 41.2%

 

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Product Segment Analysis

The product segment is divided into small-molecule drug products and small-molecule API. The small molecule API segment dominated the market, with a market share of around 59% in 2022. The main driver of this expansion is the increase in demand for innovators working with small molecules. Moreover, a sizable number of novel APIs have been approved by the US FDA in recent years. For example, 52 novel molecular entities were approved by the FDA in the United States in 2022. Future segmental expansion is anticipated to be supported by similar approvals.

Stage Type Segment Analysis

The stage type segment is divided into clinical, commercial, and preclinical. The clinical segment dominated the market, with a market share of around 42% in 2022. A significant number of clinical-stage drugs are small molecular drugs. In addition, the amount spent on pharmaceutical R&D is always rising. As per the World Preview study, the aggregate research and development expenditure on pharmaceuticals was valued at USD 238.0 billion in 2022. This amount is anticipated to rise to USD 285.0 billion by 2028. So, a spike in R&D spending is anticipated to accelerate the expansion of the clinical segment.

Customer Type Segment Analysis

The customer type segment is divided into biotechnology and pharmaceutical. The pharmaceutical segment dominated the market, with a market share of around 54% in 2022. The main driver of the segment's growth is the rise in the global number of small-molecule drug launches.

Therapeutic Area Segment Analysis

The therapeutic area segment is divided into oncology, neurology, infectious disease, cardiovascular disease, respiratory disorders, metabolic disorders, and others. The oncology segment dominated the market, with a market share of around 22% in 2022. Reasons driving the segment's growth include the rise in financing for the research of small molecule oncology medicines, the major government reimbursement policies, and the increasing number of cancer cases worldwide.

Some of the Key Market Players:
  • Cambrex Corporation
  • Thermo Fisher Scientific Inc.
  • Lonza Group Ltd
  • Syngene International Limited
  • Piramal Pharma Solutions
  • Labcorp Drug Development
  • Eurofins Scientific
  • Catalent
  • Jubilant Pharmova Limited
  • Wuxi AppTec
  • Almac Group
  • Recipharm AB

Report Description:

Attribute Description
Market Size Revenue (USD Billion)
Market size value in 2022 USD 47.8 Billion
Market size value in 2032 USD 84.0 Billion
CAGR (2023 to 2032) 5.8%
Historical data 2019-2021
Base Year 2022
Forecast 2023-2032
Region The regions analyzed for the market are Asia Pacific, Europe, South America, North America, and Middle East & Africa. Furthermore, the regions are further analyzed at the country level.
Segments Product, Stage Type, Customer Type, Therapeutic Area

Frequesntly Asked Questions

As per The Brainy Insights, the size of the small molecule CDMO market was valued at USD 47.8 billion in 2022 to USD 84.0 billion by 2032.

The global small molecule CDMO market is growing at a CAGR of 5.8% during the forecast period 2023-2032.

Asia Pacific emerged as the largest small molecule CDMO market.

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This study forecasts global, regional, and country revenue from 2019 to 2032. The Brainy Insights has segmented the global small molecule CDMO market based on the below-mentioned segments:

Global Small Molecule CDMO Market By Product:

  • Small Molecule Drug Product
  • Small Molecule API 

Global Small Molecule CDMO Market By Stage Type:

  • Clinical
  • Commercial
  • Preclinical

Global Small Molecule CDMO Market By Customer Type:

  • Biotechnology
  • Pharmaceutical

Global Small Molecule CDMO Market By Therapeutic Area:

  • Oncology
  • Neurology
  • Infectious Disease
  • Cardiovascular Disease
  • Respiratory Disorders
  • Metabolic Disorders
  • Others

Global Small Molecule CDMO Market By Region:                     

  • North America
    • U.S.
    • Canada
    • Mexico
  • Europe
    • Germany
    • France
    • U.K.
    • Italy
    • Spain
  • Asia-Pacific
    • Japan
    • China
    • India
  • South America
    • Brazil
  • Middle East and Africa  
    • UAE
    • South Africa

Methodology

Research has its special purpose to undertake marketing efficiently. In this competitive scenario, businesses need information across all industry verticals; the information about customer wants, market demand, competition, industry trends, distribution channels etc. This information needs to be updated regularly because businesses operate in a dynamic environment. Our organization, The Brainy Insights incorporates scientific and systematic research procedures in order to get proper market insights and industry analysis for overall business success. The analysis consists of studying the market from a miniscule level wherein we implement statistical tools which helps us in examining the data with accuracy and precision. 

Our research reports feature both; quantitative and qualitative aspects for any market. Qualitative information for any market research process are fundamental because they reveal the customer needs and wants, usage and consumption for any product/service related to a specific industry. This in turn aids the marketers/investors in knowing certain perceptions of the customers. Qualitative research can enlighten about the different product concepts and designs along with unique service offering that in turn, helps define marketing problems and generate opportunities. On the other hand, quantitative research engages with the data collection process through interviews, e-mail interactions, surveys and pilot studies. Quantitative aspects for the market research are useful to validate the hypotheses generated during qualitative research method, explore empirical patterns in the data with the help of statistical tools, and finally make the market estimations.

The Brainy Insights offers comprehensive research and analysis, based on a wide assortment of factual insights gained through interviews with CXOs and global experts and secondary data from reliable sources. Our analysts and industry specialist assume vital roles in building up statistical tools and analysis models, which are used to analyse the data and arrive at accurate insights with exceedingly informative research discoveries. The data provided by our organization have proven precious to a diverse range of companies, facilitating them to address issues such as determining which products/services are the most appealing, whether or not customers use the product in the manner anticipated, the purchasing intentions of the market and many others.

Our research methodology encompasses an idyllic combination of primary and secondary initiatives. Key phases involved in this process are listed below:

MARKET RESEARCH PROCESS

Data Procurement:

The phase involves the gathering and collecting of market data and its related information with the help of different sources & research procedures.

The data procurement stage involves in data gathering and collecting through various data sources.

This stage involves in extensive research. These data sources includes:

Purchased Database: Purchased databases play a crucial role in estimating the market sizes irrespective of the domain. Our purchased database includes:

  • The organizational databases such as D&B Hoovers, and Bloomberg that helps us to identify the competitive scenario of the key market players/organizations along with the financial information.
  • Industry/Market databases such as Statista, and Factiva provides market/industry insights and deduce certain formulations. 
  • We also have contractual agreements with various reputed data providers and third party vendors who provide information which are not limited to:
    • Import & Export Data
    • Business Trade Information
    • Usage rates of a particular product/service on certain demographics mainly focusing on the unmet prerequisites

Primary Research: The Brainy Insights interacts with leading companies and experts of the concerned domain to develop the analyst team’s market understanding and expertise. It improves and substantiates every single data presented in the market reports. Primary research mainly involves in telephonic interviews, E-mail interactions and face-to-face interviews with the raw material providers, manufacturers/producers, distributors, & independent consultants. The interviews that we conduct provides valuable data on market size and industry growth trends prevailing in the market. Our organization also conducts surveys with the various industry experts in order to gain overall insights of the industry/market. For instance, in healthcare industry we conduct surveys with the pharmacists, doctors, surgeons and nurses in order to gain insights and key information of a medical product/device/equipment which the customers are going to usage. Surveys are conducted in the form of questionnaire designed by our own analyst team. Surveys plays an important role in primary research because surveys helps us to identify the key target audiences of the market. Additionally, surveys helps to identify the key target audience engaged with the market. Our survey team conducts the survey by targeting the key audience, thus gaining insights from them. Based on the perspectives of the customers, this information is utilized to formulate market strategies. Moreover, market surveys helps us to understand the current competitive situation of the industry. To be precise, our survey process typically involve with the 360 analysis of the market. This analytical process begins by identifying the prospective customers for a product or service related to the market/industry to obtain data on how a product/service could fit into customers’ lives.

Secondary Research: The secondary data sources includes information published by the on-profit organizations such as World bank, WHO, company fillings, investor presentations, annual reports, national government documents, statistical databases, blogs, articles, white papers and others. From the annual report, we analyse a company’s revenue to understand the key segment and market share of that organization in a particular region. We analyse the company websites and adopt the product mapping technique which is important for deriving the segment revenue. In the product mapping method, we select and categorize the products offered by the companies catering to domain specific market, deduce the product revenue for each of the companies so as to get overall estimation of the market size. We also source data and analyses trends based on information received from supply side and demand side intermediaries in the value chain. The supply side denotes the data gathered from supplier, distributor, wholesaler and the demand side illustrates the data gathered from the end customers for respective market domain.

The supply side for a domain specific market is analysed by:

  • Estimating and projecting penetration rates through analysing product attributes, availability of internal and external substitutes, followed by pricing analysis of the product.
  • Experiential assessment of year-on-year sales of the product by conducting interviews.

The demand side for the market is estimated through:

  • Evaluating the penetration level and usage rates of the product.
  • Referring to the historical data to determine the growth rate and evaluate the industry trends

In-house Library: Apart from these third-party sources, we have our in-house library of qualitative and quantitative information. Our in-house database includes market data for various industry and domains. These data are updated on regular basis as per the changing market scenario. Our library includes, historic databases, internal audit reports and archives.

Sometimes there are instances where there is no metadata or raw data available for any domain specific market. For those cases, we use our expertise to forecast and estimate the market size in order to generate comprehensive data sets. Our analyst team adopt a robust research technique in order to produce the estimates:

  • Applying demographic along with psychographic segmentation for market evaluation
  • Determining the Micro and Macro-economic indicators for each region 
  • Examining the industry indicators prevailing in the market. 

Data Synthesis: This stage involves the analysis & mapping of all the information obtained from the previous step. It also involves in scrutinizing the data for any discrepancy observed while data gathering related to the market. The data is collected with consideration to the heterogeneity of sources. Robust scientific techniques are in place for synthesizing disparate data sets and provide the essential contextual information that can orient market strategies. The Brainy Insights has extensive experience in data synthesis where the data passes through various stages:

  • Data Screening: Data screening is the process of scrutinising data/information collected from primary research for errors and amending those collected data before data integration method. The screening involves in examining raw data, identifying errors and dealing with missing data. The purpose of the data screening is to ensure data is correctly entered or not. The Brainy Insights employs objective and systematic data screening grades involving repeated cycles of quality checks, screening and suspect analysis.
  • Data Integration: Integrating multiple data streams is necessary to produce research studies that provide in-depth picture to the clients. These data streams come from multiple research studies and our in house database. After screening of the data, our analysts conduct creative integration of data sets, optimizing connections between integrated surveys and syndicated data sources. There are mainly 2 research approaches that we follow in order to integrate our data; top down approach and bottom up approach.

Market Deduction & Formulation: The final stage comprises of assigning data points at appropriate market spaces so as to deduce feasible conclusions. Analyst perspective & subject matter expert based holistic form of market sizing coupled with industry analysis also plays a crucial role in this stage.

This stage involves in finalization of the market size and numbers that we have collected from data integration step. With data interpolation, it is made sure that there is no gap in the market data. Successful trend analysis is done by our analysts using extrapolation techniques, which provide the best possible forecasts for the market.

Data Validation & Market Feedback: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helps us finalize data-points to be used for final calculations.

The Brainy Insights interacts with leading companies and experts of the concerned domain to develop the analyst team’s market understanding and expertise. It improves and substantiates every single data presented in the market reports. The data validation interview and discussion panels are typically composed of the most experienced industry members. The participants include, however, are not limited to:

  • CXOs and VPs of leading companies’ specific to sector
  • Purchasing managers, technical personnel, end-users
  • Key opinion leaders such as investment bankers, and industry consultants

Moreover, we always validate our data and findings through primary respondents from all the major regions we are working on.

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