Nasal Drug Delivery Market

Nasal Drug Delivery Market Size by Container (Non-pressurized and Pressurized), Dosage Form (Drop, Powder, Spray, and Gel), System (Unit-Dose, Multi-Dose, and Metered-Dose), Application (Cystic Fibrosis, COPD (Chronic Obstructive Pulmonary Disease), Nasal Congestion, Asthma, Rhinitis, and Others), End User (Hospitals & Clinics, and Home Care), Distribution Channel (Offline and Online), Regions, Global Industry Analysis, Share, Growth, Trends, and Forecast 2024 to 2033

Base Year: 2023 Historical Data: 2020-22
  • Report ID: TBI-13890
  • Published Date: Sep, 2024
  • Pages: 236
  • Category: Healthcare
  • Format: PDF
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The global nasal drug delivery market was valued at USD 76.21 billion in 2023, which is anticipated to grow at a CAGR of 7.5% from 2024 to 2033. The significance of the systemic impacts of drugs administered through the nasal route have developed over recent years. Nasal administration presents an interesting option for accomplishing systemic drug outcomes to the parenteral route, that can be cumbersome, or oral administration, that can lead to unacceptably minimal bioavailability. The nasal epithelium is an extremely permeable monolayer, the submucosa is amply vascularised, and hepatic first-pass metabolism is averted post nasal administration. Another attractive aspect includes the extremely large surface region of the nasal cavity and the comparatively high blood flow, that promotes quick absorption. Also, self-medication is simple and comfortable.

Market Introduction:

The method of transferring a medication/drug into the body to deliver an adequate therapeutic result is known as drug delivery. Numerous methods are commonly applied for the delivery of the medication. Pulmonary and nasal routes are considered to be the most predominant types for transporting the drug. Nasal drug delivery is a suitable delivery method for drugs that are active in minimal dosages like proteins and peptides. The nasal path avoids hepatic first pass exclusion linked with oral transmission. The speedy initiation of the therapeutic consequence is feasible owing to the large surface field of the nasal mucosa. This procedure has great possibility for non-intrusiveness, no first-pass assimilation, and straight to the central nervous system (CNS) transfer. The possibilities in the global market for the nasal drug delivery systems have derived huge spending by major companies in research and development endeavours. Furthermore, low labour and clinical trials costs in the developing countries will also aid in attracting major market players to such nations and will mark an exponential progress in the upcoming years. The innovative nasal drug delivery tools are expected to arrive in the market and flourish significantly in the forthcoming years due to the prevailing awareness about nasal drug delivery and the apparent benefits of intranasal administration. The projections in the worldwide market for the intranasal drug delivery systems have attracted huge financing by key organizations in the research and development activities. The technological developments in several of the nasal drug transfer systems presently, comprises of the carrier technology and powder preparation, envisioned for augmented medicine absorption via its muco-adhesive features and a transmission device technology envisioned for simple use, and complete and constant transfer of intranasal powder preparations.

Nasal Drug Delivery Market Size

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Recent Development
  • In March 2023, The Food and Drug Administration (FDA) approved Amphastar’s New Drug Application (NDA) for naloxone hydrochloride nasal spray 4mg for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression for adult and paediatric patients. Naloxone hydrochloride nasal spray is an opioid antagonist designed using the Company’s proprietary nasal delivery device. It is a prescription medication intended for immediate administration as emergency therapy in settings where opioids may be present. The product is supplied as a carton containing 2 unit-dose devices; each device delivers a single spray containing 4mg of naloxone hydrochloride (equivalent to 3.6mg of naloxone). The device is ready to use and does not require priming or testing prior to administration.
  • In January 2023, Aptar Pharma announced the launch of APF Futurity, its first metal-free, multidose nasal spray pump developed to deliver nasal saline and other comparable over the counter (OTC). Specifically designed for recyclability, APF Futurity is Aptar Pharma’s first highly recyclable nasal spray pump, having achieved a Class AA certification from cyclos-HTP for recycling streams in Europe. APF Futurity is made from polyolefin materials with no metal parts or recycling disruptors, thereby minimizing separation efforts in recycling streams and supporting a higher quality of recyclates. Part of Aptar Pharma’s Futurity sustainable solutions platform, APF Futurity meets a growing consumer need for increased access to recyclable products.  When used in combination with a high-density polyethylene (HDPE) or polypropylene (PP) container bottle, a product with the APF Futurity pump can be conveniently recycled as one piece when empty after use, with no need to separate or detach any parts or materials before disposal, a key user benefit.
  • In December 2022, Virpax Pharmaceuticals, Inc., a company specializing in developing non-addictive products for pain management, post-traumatic stress disorder, central nervous system (CNS) disorders and viral barrier indications, announced that it has received pre-Investigational New Drug (PIND) application guidance from the U.S. Food and Drug Administration (FDA) for NobrXiol, the Company’s product candidate for the delivery of cannabidiol in the management of epilepsy in children and adults. NobrXiol utilizes the Nanomerics Molecular Envelope Technology (MET) as its delivery system to cross the blood brain barrier, propelling the cannabidiol nanoparticles through the nose to the brain via the olfactory nerve. The main purpose of a pre-IND submission is to obtain FDA guidance on the overall development plan for a new drug and to identify any need for further data prior to submitting the IND.

Market Dynamics:

Drivers

Growing preference for nasal drug delivery- Factors such as increasing patient inclination for nasal drug delivery and growing acceptance of self-administration of drugs are driving the progress of nasal drug delivery market. The easy administration and enhanced efficacy have improved patient inclination for the nasal drug transfer which subsequently has boosted the demand for global market for the nasal drug delivery. Due to the higher permeability and subdued enzymatic environment of the nasal opening, and avoidance of the hepatic first pass metabolism, nasal medication delivery is suitable for systemic transport of medicine molecule through the nose. Various drug delivery tools for nasal use of liquid, solid, and semisolid formulation are explored to deliver the drugs to the treat extremely critical CNS (central nervous system) diseases (i.e., Parkinson’s and Alzheimer’s) since it demands quick and definite aiming of medicines to brain.

Opportunities:

High incidence of lifestyle diseases- Elevated prevalence of cardiovascular disorders, augmented diabetes and cancer cases, and rising demand for home-based healthcare devices are also propelling the nasal drug delivery market growth across the world. Further aspects that are expected to fuel this market are rapid R&D action and reception of novel drug delivery approaches and devices, reformulation of oral and injections medications into the preparations to be directed by the nasal way, and quick start of action.

Challenges:

Rigorous regulatory guidelines- The nasal drug delivery devices need go through a thorough process for getting approval. The assessing products are checked on numerous parameters and need to comply with the required guidelines. This is a time utilizing and capital-intensive procedure.

Regional segmentation analysis:

The regions analysed for the market study include North America, South America, Europe, the Middle East, and Africa, and Asia Pacific. North America emerged as the most significant global nasal drug delivery market, with a 36.7% market revenue share in 2023. Factors such as high awareness, availability of advanced healthcare infrastructure, presence of market leading companies in the region, increasing demand for self-administration, and high spending capacity are expected to maintain the dominance of North America in the global nasal drug delivery market.

North America Region Nasal Drug Delivery Market Share in 2023 - 36.7%

 

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Container Segment Analysis

The container segment is divided into non-pressurized and pressurized. The non-pressurized container segment dominated, with a market share of around 80% in 2023. Rising awareness concerning the use of non-pressurized containers is the key reason for elevated market share of non-pressurized containers.

Dosage Form Segment Analysis

The dosage form segment is divided into drop, powder, spray, and gel. The spray segment dominated the dosage form segment due to rising prevalence of infectious diseases.

Application Segment Analysis

The application segment is divided into cystic fibrosis, COPD (chronic obstructive pulmonary disease), nasal congestion, asthma, rhinitis, and others. The COPD (chronic obstructive pulmonary disease) segment dominated the application segment.

Some of the Key Market Players:
  • Becton, Dickinson and Company
  • GlaxoSmithKline PLC
  • OptiNose, Inc.
  • AstraZeneca PLC
  • B.F. Ascher & Company, Inc.
  • Pfizer, Inc.
  • PendoPharm, Inc.
  • ENT Technologies Pty. Ltd.
  • Promius Pharma, LLC
  • NAVEH Pharma Ltd.
  • Cadila Pharmaceuticals Ltd.
  • Douglas Pharmaceuticals Ltd.

Report Description: 

Attribute Description
Market Size Revenue (USD Billion)
Market size value in 2023 USD 76.21 Billion
Market size value in 2033 USD 157.06 Billion
CAGR (2024 to 2033) 7.5%
Historical data 2020-2022
Base Year 2023
Forecast 2024-2033
Region The regions analyzed for the market are Asia Pacific, Europe, South America, North America, and Middle East & Africa. Furthermore, the regions are further analyzed at the country level.
Segments Container, Dosage Form, System, Application, End User, Distribution Channel

Frequesntly Asked Questions

As per The Brainy Insights, the size of the nasal drug delivery market was valued at USD 76.21 Billion in 2023 & USD 157.06 Billion by 2033.

Global nasal drug delivery market is growing at a CAGR of 7.5% during the forecast period 2024-2033.

North America region emerged as the largest market for the nasal drug delivery.

The growing preference for nasal drug delivery is a significant driving factor for the growth of the nasal drug delivery market.

The high incidence of lifestyle diseases is a significant opportunity for the growth of the nasal drug delivery market.

Rigorous regulatory guidelines is a significant challenging factor for the growth of the nasal drug delivery market.

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This study forecasts revenue at global, regional, and country levels from 2020 to 2033. The Brainy Insights has segmented the global nasal drug delivery market based on below mentioned segments:

Global Nasal Drug Delivery by Container:

  • Non-pressurized
  • Pressurized

Global Nasal Drug Delivery by Dosage Form:

  • Drop
  • Powder
  • Spray
  • Gel

Global Nasal Drug Delivery by System:

  • Unit-Dose
  • Multi-Dose
  • Metered-Dose

Global Nasal Drug Delivery by Application:

  • Cystic Fibrosis
  • COPD (Chronic Obstructive Pulmonary Disease)
  • Nasal Congestion
  • Asthma
  • Rhinitis
  • Others

Global Nasal Drug Delivery by End User:

  • Hospitals & Clinics
  • Home Care

Global Nasal Drug Delivery by Region:

  • North America
    • U.S.
    • Canada
    • Mexico
  • Europe
    • Germany
    • France
    • U.K.
    • Italy
    • Spain
  • Asia-Pacific
    • Japan
    • China
    • India
  • South America
    • Brazil
  • Middle East and Africa  
    • UAE
    • South Africa

Methodology

Research has its special purpose to undertake marketing efficiently. In this competitive scenario, businesses need information across all industry verticals; the information about customer wants, market demand, competition, industry trends, distribution channels etc. This information needs to be updated regularly because businesses operate in a dynamic environment. Our organization, The Brainy Insights incorporates scientific and systematic research procedures in order to get proper market insights and industry analysis for overall business success. The analysis consists of studying the market from a miniscule level wherein we implement statistical tools which helps us in examining the data with accuracy and precision. 

Our research reports feature both; quantitative and qualitative aspects for any market. Qualitative information for any market research process are fundamental because they reveal the customer needs and wants, usage and consumption for any product/service related to a specific industry. This in turn aids the marketers/investors in knowing certain perceptions of the customers. Qualitative research can enlighten about the different product concepts and designs along with unique service offering that in turn, helps define marketing problems and generate opportunities. On the other hand, quantitative research engages with the data collection process through interviews, e-mail interactions, surveys and pilot studies. Quantitative aspects for the market research are useful to validate the hypotheses generated during qualitative research method, explore empirical patterns in the data with the help of statistical tools, and finally make the market estimations.

The Brainy Insights offers comprehensive research and analysis, based on a wide assortment of factual insights gained through interviews with CXOs and global experts and secondary data from reliable sources. Our analysts and industry specialist assume vital roles in building up statistical tools and analysis models, which are used to analyse the data and arrive at accurate insights with exceedingly informative research discoveries. The data provided by our organization have proven precious to a diverse range of companies, facilitating them to address issues such as determining which products/services are the most appealing, whether or not customers use the product in the manner anticipated, the purchasing intentions of the market and many others.

Our research methodology encompasses an idyllic combination of primary and secondary initiatives. Key phases involved in this process are listed below:

MARKET RESEARCH PROCESS

Data Procurement:

The phase involves the gathering and collecting of market data and its related information with the help of different sources & research procedures.

The data procurement stage involves in data gathering and collecting through various data sources.

This stage involves in extensive research. These data sources includes:

Purchased Database: Purchased databases play a crucial role in estimating the market sizes irrespective of the domain. Our purchased database includes:

  • The organizational databases such as D&B Hoovers, and Bloomberg that helps us to identify the competitive scenario of the key market players/organizations along with the financial information.
  • Industry/Market databases such as Statista, and Factiva provides market/industry insights and deduce certain formulations. 
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    • Usage rates of a particular product/service on certain demographics mainly focusing on the unmet prerequisites

Primary Research: The Brainy Insights interacts with leading companies and experts of the concerned domain to develop the analyst team’s market understanding and expertise. It improves and substantiates every single data presented in the market reports. Primary research mainly involves in telephonic interviews, E-mail interactions and face-to-face interviews with the raw material providers, manufacturers/producers, distributors, & independent consultants. The interviews that we conduct provides valuable data on market size and industry growth trends prevailing in the market. Our organization also conducts surveys with the various industry experts in order to gain overall insights of the industry/market. For instance, in healthcare industry we conduct surveys with the pharmacists, doctors, surgeons and nurses in order to gain insights and key information of a medical product/device/equipment which the customers are going to usage. Surveys are conducted in the form of questionnaire designed by our own analyst team. Surveys plays an important role in primary research because surveys helps us to identify the key target audiences of the market. Additionally, surveys helps to identify the key target audience engaged with the market. Our survey team conducts the survey by targeting the key audience, thus gaining insights from them. Based on the perspectives of the customers, this information is utilized to formulate market strategies. Moreover, market surveys helps us to understand the current competitive situation of the industry. To be precise, our survey process typically involve with the 360 analysis of the market. This analytical process begins by identifying the prospective customers for a product or service related to the market/industry to obtain data on how a product/service could fit into customers’ lives.

Secondary Research: The secondary data sources includes information published by the on-profit organizations such as World bank, WHO, company fillings, investor presentations, annual reports, national government documents, statistical databases, blogs, articles, white papers and others. From the annual report, we analyse a company’s revenue to understand the key segment and market share of that organization in a particular region. We analyse the company websites and adopt the product mapping technique which is important for deriving the segment revenue. In the product mapping method, we select and categorize the products offered by the companies catering to domain specific market, deduce the product revenue for each of the companies so as to get overall estimation of the market size. We also source data and analyses trends based on information received from supply side and demand side intermediaries in the value chain. The supply side denotes the data gathered from supplier, distributor, wholesaler and the demand side illustrates the data gathered from the end customers for respective market domain.

The supply side for a domain specific market is analysed by:

  • Estimating and projecting penetration rates through analysing product attributes, availability of internal and external substitutes, followed by pricing analysis of the product.
  • Experiential assessment of year-on-year sales of the product by conducting interviews.

The demand side for the market is estimated through:

  • Evaluating the penetration level and usage rates of the product.
  • Referring to the historical data to determine the growth rate and evaluate the industry trends

In-house Library: Apart from these third-party sources, we have our in-house library of qualitative and quantitative information. Our in-house database includes market data for various industry and domains. These data are updated on regular basis as per the changing market scenario. Our library includes, historic databases, internal audit reports and archives.

Sometimes there are instances where there is no metadata or raw data available for any domain specific market. For those cases, we use our expertise to forecast and estimate the market size in order to generate comprehensive data sets. Our analyst team adopt a robust research technique in order to produce the estimates:

  • Applying demographic along with psychographic segmentation for market evaluation
  • Determining the Micro and Macro-economic indicators for each region 
  • Examining the industry indicators prevailing in the market. 

Data Synthesis: This stage involves the analysis & mapping of all the information obtained from the previous step. It also involves in scrutinizing the data for any discrepancy observed while data gathering related to the market. The data is collected with consideration to the heterogeneity of sources. Robust scientific techniques are in place for synthesizing disparate data sets and provide the essential contextual information that can orient market strategies. The Brainy Insights has extensive experience in data synthesis where the data passes through various stages:

  • Data Screening: Data screening is the process of scrutinising data/information collected from primary research for errors and amending those collected data before data integration method. The screening involves in examining raw data, identifying errors and dealing with missing data. The purpose of the data screening is to ensure data is correctly entered or not. The Brainy Insights employs objective and systematic data screening grades involving repeated cycles of quality checks, screening and suspect analysis.
  • Data Integration: Integrating multiple data streams is necessary to produce research studies that provide in-depth picture to the clients. These data streams come from multiple research studies and our in house database. After screening of the data, our analysts conduct creative integration of data sets, optimizing connections between integrated surveys and syndicated data sources. There are mainly 2 research approaches that we follow in order to integrate our data; top down approach and bottom up approach.

Market Deduction & Formulation: The final stage comprises of assigning data points at appropriate market spaces so as to deduce feasible conclusions. Analyst perspective & subject matter expert based holistic form of market sizing coupled with industry analysis also plays a crucial role in this stage.

This stage involves in finalization of the market size and numbers that we have collected from data integration step. With data interpolation, it is made sure that there is no gap in the market data. Successful trend analysis is done by our analysts using extrapolation techniques, which provide the best possible forecasts for the market.

Data Validation & Market Feedback: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helps us finalize data-points to be used for final calculations.

The Brainy Insights interacts with leading companies and experts of the concerned domain to develop the analyst team’s market understanding and expertise. It improves and substantiates every single data presented in the market reports. The data validation interview and discussion panels are typically composed of the most experienced industry members. The participants include, however, are not limited to:

  • CXOs and VPs of leading companies’ specific to sector
  • Purchasing managers, technical personnel, end-users
  • Key opinion leaders such as investment bankers, and industry consultants

Moreover, we always validate our data and findings through primary respondents from all the major regions we are working on.

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