Induced Pluripotent Stem Cell (iPSC) Market

Induced Pluripotent Stem Cell (iPSC) Market Size By Derived Cell (Fibroblasts, Cardiomyocytes, Hepatocytes, Amniotic Cells, and Others), and By Application (Academic Research, Toxicity Screening, Manufacturing, Drug Development & Discovery, and Regenerative Medicine), Regions, Global Industry Analysis, Share, Growth, Trends, and Forecast 2024 to 2033

Base Year: 2023 Historical Data: 2020-22
  • Report ID: TBI-14193
  • Published Date: Mar, 2024
  • Pages: 238
  • Category: Healthcare
  • Format: PDF
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The global induced pluripotent stem cell (iPSC) market was valued at USD 2.1 billion in 2023, growing at a CAGR of 9.6% from 2024 to 2033. The market is expected to reach USD 5.2 billion by 2033. Due to the growing need for vaccine production, higher expenditures in the industry, and an expanding application portfolio from ongoing research and development efforts, the iPSC market is expanding quickly. The induced pluripotent stem cell (iPSC) market is growing due to the active infrastructure development undertaken by public and private institutions to support iPSC research.

Market Introduction:

Cells taken from adult somatic tissues are called induced pluripotent stem cells (iPSCs), and the introduction of particular genes and agents reprograms them. Through this reprogramming process, the iPSCs can develop pluripotent characteristics akin to embryonic stem cells. With their ability to reprogram cells from the same individual,iPSCs offer a useful tool for illness modelling. Retroviruses are employed as vectors to transfer the genes and other components required for iPSC reprogramming. iPSCs are used in many domains, such as gene treatments, toxicity research, drug discovery and development, and disease modelling. They have demonstrated promise in treating several cancers, diabetes mellitus, and cardiovascular illnesses. Because human iPSCs, in particular, have genotypes specific to certain diseases, new therapeutic methods customised for each patient are made possible. As iPSCs closely mimic the genetic composition of their donors, they enable researchers to examine diseases in a more pertinent and customised way. It creates new opportunities for comprehending the workings of disease systems and creating tailored treatments. iPSCs have the power to transform the area of regenerative medicine and offer cutting-edge treatments for a wide range of illnesses.

Induced Pluripotent Stem Cell (iPSC) Market Size

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Recent Development

In August 2021, for an undisclosed sum, the US pharmaceutical company Catalent purchased RheinCell Therapeutics GmbH, a German business that developed human induced pluripotent stem cells (iPSCs). With this acquisition, Catalent can create more advanced cell therapies using iPSCs and increase its market share in the gene and cell therapy industries.

In August 2021, To support its research and development programme, clinical operations, and commercialization activities for off-the-shelf pluripotent stem cell-CAR-NK (Chimeric Antigen Receptor-Natural Killer) products, HebeCell Corp. successfully raised USD 53 million in funding.

In April 2022, Promising preclinical findings demonstrated the tumor-killing capacity of Editas Medicine, Inc.'s NK cell therapy derived from induced pluripotent stem cells (iPSCs). The in-vitro and in-vivo outcomes show how well this novel strategy targets and eradicates tumours. 

Market Dynamics:

Drivers

Growing need to culture human iPSCs- Businesses and research organisations are working to create induced pluripotent stem cells (iPSCs) with as little chance of genetic abnormalities leading to cancerous transformation as possible. The necessity to develop human iPSCs without using animal cells is becoming increasingly apparent globally, and major efforts are being made to accomplish this goal. Attention is also paid to standardising the environment for cell culture and differentiation.

Restraints:

High cost- The high expenses involved in iPSC development and commercialisation continue to be a significant obstacle to their widespread use. Addressing the bottleneck of standardisation of differentiation methods is crucial. From the perspective of effectiveness and safety, the incomplete knowledge of epigenetic modifications during reprogramming is especially concerning. Players in the market should concentrate on improving methods for producing clinical-gradeiPSCs quickly and affordably. Collaborations between academics and industry could improve the uses of iPSC platforms. Although laws vary from place to region, the market would benefit from supportive laws and rules. Continuing efforts to bank stem cells may make getting iPSC lines for scientific investigations easier.

Opportunities:

Increasing research funding- In recent years, there has been a significant increase in financing for stem cell research from both the public and corporate sectors. This has fueled advancements in induced pluripotent stem cells (iPSCs), broadening their applications and stimulating additional study. Budgets for stem cell research have increased dramatically in countries like China, Japan, and numerous European countries; special attention has been paid to the potential application of iPSC technology in developing personalised regenerative treatments. For instance, government funding for iPSC studies had increased during 2020, according to a 2022 statement from the U.K. Stem Cell Foundation. Nonprofits dedicated to stem cell research have also seen an increase in private donations; the California Institute for Regenerative Medicine said in late 2021 that the year's private contributions had topped $300 million.

Regional segmentation analysis:

The regions analyzed for the market include North America, Europe, South America, Asia Pacific, the Middle East, and Africa. North America emerged as the most significant global induced pluripotent stem cell (iPSC) market, with a 36.7% market revenue share in 2023.

The region benefits from the significant financing that government and private sectors give to research institutions and the strong presence of important industry companies. Furthermore, North America has a strong infrastructure for application and research fields like toxicity screening and tissue engineering, which supports market expansion. Furthermore, research involving induced pluripotent stem cells (iPSCs) is supported by organisations such as the National Institute of Health (NIH), the California Institute for Regenerative Medicine (CIRM), the National Institute of Neurological Disorders and Stroke (NINDS), and many others.

North America Region Induced Pluripotent Stem Cell (iPSC) Market Share in 2023 - 36.7%

 

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Derived Cell Segment Analysis

The derived cell segment is divided into fibroblasts, cardiomyocytes, hepatocytes, amniotic cells, and others. The cardiomyocytes segment dominated the market, with a market share of around 29% in 2023. As the company uses human-derived iPSCs, researchers can benefit from a steady supply of cardiomyocytes with a common genetic background for various investigations. This market sector is growing because of the increased utility of these cells in applications, including electrophysiology and metabolism studies.

Application Segment Analysis

The application segment is divided into academic research, toxicity screening, manufacturing, drug development & discovery, and regenerative medicine. The drug development & discovery segment dominated the market, with a market share of around 25% in 2023. The segment's growth is driven by major pharmaceutical companies' great interest in gaining iPSC knowledge due to its inherent benefits and prospective income streams.

Some of the Key Market Players:
  • FUJIFILM Holdings Corporation (Cellular Dynamics)
  • Takara Bio Inc
  • Axol Bioscience Ltd
  • Ncardia
  • REPROCELL USA, Inc
  • Thermo Fisher Scientific Inc
  • Astellas Pharma Inc.
  • Cynata Therapeutics Limited
  • Fate Therapeutics
  • ViaCyte, Inc

Report Description:

Attribute Description
Market Size Revenue (USD Billion)
Market size value in 2023 USD 2.1 Billion
Market size value in 2033 USD 5.2 Billion
CAGR (2024 to 2033) 9.6%
Historical data 2020-2022
Base Year 2023
Forecast 2024-2033
Region The regions analyzed for the market are Asia Pacific, Europe, South America, North America, and Middle East & Africa. Furthermore, the regions are further analyzed at the country level.
Segments Derived Cell, Application

Frequesntly Asked Questions

As per The Brainy Insights, the size of the induced pluripotent stem cell (iPSC) market was valued at USD 2.1 billion in 2023 to USD 5.2 billion by 2033.

The global induced pluripotent stem cell (iPSC) market is growing at a CAGR of 9.6% during the forecast period 2024-2033.

North America emerged as the largest induced pluripotent stem cell (iPSC) market.

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This study forecasts global, regional, and country revenue from 2020 to 2033. The Brainy Insights has segmented the global induced pluripotent stem cell (iPSC) market based on the below-mentioned segments:

Global Induced Pluripotent Stem Cell (iPSC) Market By Derived Cell:

  • Fibroblasts
  • Cardiomyocytes
  • Hepatocytes
  • Amniotic Cells
  • Others

Global Induced Pluripotent Stem Cell (iPSC) Market By Application:

  • Academic Research
  • Toxicity Screening
  • Manufacturing
  • Drug Development & Discovery
  • Regenerative Medicine   

Global Induced Pluripotent Stem Cell (iPSC) Market By Region: 

  • North America
    • U.S.
    • Canada
    • Mexico
  • Europe
    • Germany
    • France
    • U.K.
    • Italy
    • Spain
  • Asia-Pacific
    • Japan
    • China
    • India
  • South America
    • Brazil
  • Middle East and Africa  
    • UAE
    • South Africa

Methodology

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Our research reports feature both; quantitative and qualitative aspects for any market. Qualitative information for any market research process are fundamental because they reveal the customer needs and wants, usage and consumption for any product/service related to a specific industry. This in turn aids the marketers/investors in knowing certain perceptions of the customers. Qualitative research can enlighten about the different product concepts and designs along with unique service offering that in turn, helps define marketing problems and generate opportunities. On the other hand, quantitative research engages with the data collection process through interviews, e-mail interactions, surveys and pilot studies. Quantitative aspects for the market research are useful to validate the hypotheses generated during qualitative research method, explore empirical patterns in the data with the help of statistical tools, and finally make the market estimations.

The Brainy Insights offers comprehensive research and analysis, based on a wide assortment of factual insights gained through interviews with CXOs and global experts and secondary data from reliable sources. Our analysts and industry specialist assume vital roles in building up statistical tools and analysis models, which are used to analyse the data and arrive at accurate insights with exceedingly informative research discoveries. The data provided by our organization have proven precious to a diverse range of companies, facilitating them to address issues such as determining which products/services are the most appealing, whether or not customers use the product in the manner anticipated, the purchasing intentions of the market and many others.

Our research methodology encompasses an idyllic combination of primary and secondary initiatives. Key phases involved in this process are listed below:

MARKET RESEARCH PROCESS

Data Procurement:

The phase involves the gathering and collecting of market data and its related information with the help of different sources & research procedures.

The data procurement stage involves in data gathering and collecting through various data sources.

This stage involves in extensive research. These data sources includes:

Purchased Database: Purchased databases play a crucial role in estimating the market sizes irrespective of the domain. Our purchased database includes:

  • The organizational databases such as D&B Hoovers, and Bloomberg that helps us to identify the competitive scenario of the key market players/organizations along with the financial information.
  • Industry/Market databases such as Statista, and Factiva provides market/industry insights and deduce certain formulations. 
  • We also have contractual agreements with various reputed data providers and third party vendors who provide information which are not limited to:
    • Import & Export Data
    • Business Trade Information
    • Usage rates of a particular product/service on certain demographics mainly focusing on the unmet prerequisites

Primary Research: The Brainy Insights interacts with leading companies and experts of the concerned domain to develop the analyst team’s market understanding and expertise. It improves and substantiates every single data presented in the market reports. Primary research mainly involves in telephonic interviews, E-mail interactions and face-to-face interviews with the raw material providers, manufacturers/producers, distributors, & independent consultants. The interviews that we conduct provides valuable data on market size and industry growth trends prevailing in the market. Our organization also conducts surveys with the various industry experts in order to gain overall insights of the industry/market. For instance, in healthcare industry we conduct surveys with the pharmacists, doctors, surgeons and nurses in order to gain insights and key information of a medical product/device/equipment which the customers are going to usage. Surveys are conducted in the form of questionnaire designed by our own analyst team. Surveys plays an important role in primary research because surveys helps us to identify the key target audiences of the market. Additionally, surveys helps to identify the key target audience engaged with the market. Our survey team conducts the survey by targeting the key audience, thus gaining insights from them. Based on the perspectives of the customers, this information is utilized to formulate market strategies. Moreover, market surveys helps us to understand the current competitive situation of the industry. To be precise, our survey process typically involve with the 360 analysis of the market. This analytical process begins by identifying the prospective customers for a product or service related to the market/industry to obtain data on how a product/service could fit into customers’ lives.

Secondary Research: The secondary data sources includes information published by the on-profit organizations such as World bank, WHO, company fillings, investor presentations, annual reports, national government documents, statistical databases, blogs, articles, white papers and others. From the annual report, we analyse a company’s revenue to understand the key segment and market share of that organization in a particular region. We analyse the company websites and adopt the product mapping technique which is important for deriving the segment revenue. In the product mapping method, we select and categorize the products offered by the companies catering to domain specific market, deduce the product revenue for each of the companies so as to get overall estimation of the market size. We also source data and analyses trends based on information received from supply side and demand side intermediaries in the value chain. The supply side denotes the data gathered from supplier, distributor, wholesaler and the demand side illustrates the data gathered from the end customers for respective market domain.

The supply side for a domain specific market is analysed by:

  • Estimating and projecting penetration rates through analysing product attributes, availability of internal and external substitutes, followed by pricing analysis of the product.
  • Experiential assessment of year-on-year sales of the product by conducting interviews.

The demand side for the market is estimated through:

  • Evaluating the penetration level and usage rates of the product.
  • Referring to the historical data to determine the growth rate and evaluate the industry trends

In-house Library: Apart from these third-party sources, we have our in-house library of qualitative and quantitative information. Our in-house database includes market data for various industry and domains. These data are updated on regular basis as per the changing market scenario. Our library includes, historic databases, internal audit reports and archives.

Sometimes there are instances where there is no metadata or raw data available for any domain specific market. For those cases, we use our expertise to forecast and estimate the market size in order to generate comprehensive data sets. Our analyst team adopt a robust research technique in order to produce the estimates:

  • Applying demographic along with psychographic segmentation for market evaluation
  • Determining the Micro and Macro-economic indicators for each region 
  • Examining the industry indicators prevailing in the market. 

Data Synthesis: This stage involves the analysis & mapping of all the information obtained from the previous step. It also involves in scrutinizing the data for any discrepancy observed while data gathering related to the market. The data is collected with consideration to the heterogeneity of sources. Robust scientific techniques are in place for synthesizing disparate data sets and provide the essential contextual information that can orient market strategies. The Brainy Insights has extensive experience in data synthesis where the data passes through various stages:

  • Data Screening: Data screening is the process of scrutinising data/information collected from primary research for errors and amending those collected data before data integration method. The screening involves in examining raw data, identifying errors and dealing with missing data. The purpose of the data screening is to ensure data is correctly entered or not. The Brainy Insights employs objective and systematic data screening grades involving repeated cycles of quality checks, screening and suspect analysis.
  • Data Integration: Integrating multiple data streams is necessary to produce research studies that provide in-depth picture to the clients. These data streams come from multiple research studies and our in house database. After screening of the data, our analysts conduct creative integration of data sets, optimizing connections between integrated surveys and syndicated data sources. There are mainly 2 research approaches that we follow in order to integrate our data; top down approach and bottom up approach.

Market Deduction & Formulation: The final stage comprises of assigning data points at appropriate market spaces so as to deduce feasible conclusions. Analyst perspective & subject matter expert based holistic form of market sizing coupled with industry analysis also plays a crucial role in this stage.

This stage involves in finalization of the market size and numbers that we have collected from data integration step. With data interpolation, it is made sure that there is no gap in the market data. Successful trend analysis is done by our analysts using extrapolation techniques, which provide the best possible forecasts for the market.

Data Validation & Market Feedback: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helps us finalize data-points to be used for final calculations.

The Brainy Insights interacts with leading companies and experts of the concerned domain to develop the analyst team’s market understanding and expertise. It improves and substantiates every single data presented in the market reports. The data validation interview and discussion panels are typically composed of the most experienced industry members. The participants include, however, are not limited to:

  • CXOs and VPs of leading companies’ specific to sector
  • Purchasing managers, technical personnel, end-users
  • Key opinion leaders such as investment bankers, and industry consultants

Moreover, we always validate our data and findings through primary respondents from all the major regions we are working on.

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