Global Fc fusion protein market is anticipated to reach USD 65.73 billion by 2030, at a CAGR of 11.44% from 2021 to 2030. The rising number of research and development activities for the development fc fusion protein drugs are driving the growth of the market.
Fc fusion proteins are the bioengineered polypeptides composed of crystallizable fragment (Fc) domain of IgG linked to the protein or the peptide of interest. The Fc fusion proteins are also known as Fc-Ig’s, Fc-tag protein, and Ig-based Chimeric Fusion proteins. These proteins have become valuable reagents for in-vitro and in-vivo research. Some of the examples of the binding partners of Fc fusion proteins are ligands activated upon cell-surface receptor binding, extracellular domains of receptors activated upon dimerization, bait proteins, single peptides, and signalling molecules. The gamma immunoglobulin (IgG) isotope is generally used as a basis for the Fc fusion proteins generation.
The Fc fusion proteins have plenty of biological and pharmaceutical applications, and Fc fusion proteins are being used for drug development. In the biopharmaceutical sector, the Fc fusion proteins have become the class of medicines for treating various human diseases. These proteins are also used in protein binding assays and flow cytometry. Furthermore, the Fc fusion protein can improve the solubility and stability of some binding partners. Owing to the nature of the antibody IgG-Fc, the Fc fusion protein plays a vital role in the receptor activation, in-vivo half-life, legand affinity, and dimerization.
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The Fc fusion proteins are now widely being used in therapy and prevention and treatment of various diseases. These are successfully used in multiple diseases such as immune disease, viral infection, cancer, diabetes, eye diseases, hemophilia, etc. The other significant indications for therapeutic fusion proteins are musculoskeletal conditions and inflammation, among others. Thus, growing therapeutic applications of the Fc fusion protein are fuelling the market's growth over the forecast period.
There has been a significant rise in the research and development activities of the Fc fusion protein from the past few decades. At the end of the year 2017, 50,164 patent applications were published on the therapeutic fusion protein. The U.S., China, Japan, Germany, and South Korea are the top countries with high investment in the research and development activities of the Fc fusion protein. Therefore, rising research and development activities for the development of Fc fusion protein are boosting the market’s growth over the forecast period.
Whether it's in the clinical trials phase or marketed, the Fc fusion protein is subjected to the stringent government regulations present in the market. Many countries have set their regulations for the clinical trials and marketing of Fc fusion protein drugs. The companies of the global Fc fusion protein market have to follow all of these guidelines. Therefore, the presence of stringent government regulations in the market may hamper the market's growth over the forecast period.
The Fc fusion protein biosimilars have been experiencing significant growth over the past few years. Increasing investment in the research and development activities for the development of Fc fusion protein biosimilars by the key companies further provides opportunities for the vendors in the market. Besides, the rising applications of the Fc fusion protein biosimilars for the treatment of various diseases are driving the growth. More than 11 Fc fusion protein drugs have been approved by the Food and Drug Administration (U.S. FDA), and many more are in the developing phase. Therefore, rising approvals and government initiatives for biosimilars provide future market opportunities over the forecast period.
When evaluating the manufacturing process of the Fc fusion protein, the various manufacturing issues become apparent. Some of the manufacturing process issues are flaws in the design process of Fc fusion protein and challenges regarding the quality of Fc fusion protein. In addition to this, achieving and maintaining the proper folding of each protein is one of the critical challenges in Fc fusion protein manufacturing. Therefore, the production challenges of the Fc fusion protein could hinder the growth of the market over the forecast period.
The global Fc fusion protein market has been classified based on type, therapeutic area, application, end-user, and regions.
The regions analysed for the market include North America, Europe, South America, Asia Pacific, and the Middle East and Africa. The North America region dominated the global Fc fusion protein market and accounted the major market share of 42.5% in the year 2020.
North America Fc Fusion Protein Market Share in 2020 - 42.5%
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To stay a competitive in the market, the key players of the global Fc fusion protein market are mainly focusing on research and development activities for the development of innovative Fc fusion protein drugs in the market. The key players of the market are also focusing on the gaining approval from the respective government and organization for the Fc fusion protein products.
In January 2016, Swedish Orphan Biovitrum AB announced the commercial launch of Elocta (efmoroctocog alfa), a recombinant human factor VIII Fc fusion protein with an extended half-life, for the first haemophilia A treatment in Europe.
In August 2018, Samsung Bioepis Co., Ltd. announced that it has started the phase 1 clinical trial SB26 Ulinastatin-Fc Fusion Protein to access the tolerability, safety, and pharmacokinetics.
As per The Brainy Insights, the size of the Fc fusion protein market was valued at USD 25.01 billion in 2020 and is anticipated to reach USD 65.73 billion by 2030.
Global Fc fusion protein market is growing at a CAGR of 11.44% during the forecast period 2021-2030.
The global Fc fusion protein market has been segmented based on type, therapeutic area, application, end user, and regions. The branded drugs segment led the Fc fusion protein market.
The North America region emerged as the largest market for the Fc fusion protein.
The rising research and development activities in all over the world are one of the key contributing factor for the growth of market.
The high cost and stringent government regulations could hamper the growth of the market over the forecast period.
Rising potential applications of Fc fusion drugs to treat the multiple diseases is expected to offer the future growth opportunity in the market.
Key players are Astellas Pharma US, Regeneron, Genzyme, Ligand Pharmaceuticals, Bristol-Myers Squibb, Viventia, Eli Lilly and Company, Amgen, Swedish Orphan Biovitrum AB, 3SBio Inc., and Samsung Bioepis Co., Ltd. among others.
1. Introduction
1.1. Objectives of the Study
1.2. Market Definition
1.3. Research Scope
1.4. Currency
1.5. Key Target Audience
2. Research Methodology and Assumptions
3. Executive Summary
4. Premium Insights
4.1. Porter’s Five Forces Analysis
4.2. Value Chain Analysis
4.3. Top Investment Pockets
4.3.1. Market Attractiveness Analysis By Type
4.3.2. Market Attractiveness Analysis By Therapeutic Area
4.3.3. Market Attractiveness Analysis By Application
4.3.4. Market Attractiveness Analysis By End User
4.3.5. Market Attractiveness Analysis By Region
4.4. Industry Trends
5. Market Dynamics
5.1. Market Evaluation
5.2. Drivers
5.2.1. Increasing research and development activities
5.2.2. Rising prevalence of chronic diseases
5.3. Restrains
5.3.1. High cost of Fc Fusion Protein production
5.4. Opportunities
5.4.1. Increasing clinical research on the Fc Fusion protein biosimilars
5.5. Challenges
5.5.1. Stringent government regulations
6. Global Fc Fusion Protein Market Analysis and Forecast, By Type
6.1. Segment Overview
6.2. Biosimilar Drugs
6.3. Brands Drugs
7. Global Fc Fusion Protein Market Analysis and Forecast, By Therapeutic Area
7.1. Segment Overview
7.2. Eye Diseases
7.3. Hemophilia
7.4. Autoimmune Disease
7.5. Diabetes
7.6. Others
8. Global Fc Fusion Protein Market Analysis and Forecast, By Application
8.1. Segment Overview
8.2. In vitro
8.3. In vivo
9. Global Fc Fusion Protein Market Analysis and Forecast, By End User
9.1. Segment Overview
9.2. Hospitals
9.3. Ophthalmic or oculoplastic clinics
10. Global Fc Fusion Protein Market Analysis and Forecast, By Regional Analysis
10.1. Segment Overview
10.2. North America
10.2.1. U.S.
10.2.2. Canada
10.2.3. Mexico
10.3. Europe
10.3.1. Germany
10.3.2. France
10.3.3. U.K.
10.3.4. Italy
10.3.5. Spain
10.4. Asia-Pacific
10.4.1. Japan
10.4.2. China
10.4.3. India
10.5. South America
10.5.1. Brazil
10.6. Middle East and Africa
10.6.1. UAE
10.6.2. South Africa
11. Global Fc Fusion Protein Market-Competitive Landscape
11.1. Overview
11.2. Market Share of Key Players in the Fc Fusion Protein Market
11.2.1. Global Company Market Share
11.2.2. North America Company Market Share
11.2.3. Europe Company Market Share
11.2.4. APAC Company Market Share
11.3. Competitive Situations and Trends
11.3.1. Product Launches and Developments
11.3.2. Partnerships, Collaborations, and Agreements
11.3.3. Mergers & Acquisitions
11.3.4. Expansions
12. Company Profiles
12.1. Astellas Pharma US
12.1.1. Business Overview
12.1.2. Company Snapshot
12.1.3. Company Market Share Analysis
12.1.4. Company Product Portfolio
12.1.5. Recent Developments
12.1.6. SWOT Analysis
12.2. Regeneron,
12.2.1. Business Overview
12.2.2. Company Snapshot
12.2.3. Company Market Share Analysis
12.2.4. Company Product Portfolio
12.2.5. Recent Developments
12.2.6. SWOT Analysis
12.3. Genzyme
12.3.1. Business Overview
12.3.2. Company Snapshot
12.3.3. Company Market Share Analysis
12.3.4. Company Product Portfolio
12.3.5. Recent Developments
12.3.6. SWOT Analysis
12.4. Ligand Pharmaceuticals
12.4.1. Business Overview
12.4.2. Company Snapshot
12.4.3. Company Market Share Analysis
12.4.4. Company Product Portfolio
12.4.5. Recent Developments
12.4.6. SWOT Analysis
12.5. Bristol-Myers Squibb
12.5.1. Business Overview
12.5.2. Company Snapshot
12.5.3. Company Market Share Analysis
12.5.4. Company Product Portfolio
12.5.5. Recent Developments
12.5.6. SWOT Analysis
12.6. Viventia
12.6.1. Business Overview
12.6.2. Company Snapshot
12.6.3. Company Market Share Analysis
12.6.4. Company Product Portfolio
12.6.5. Recent Developments
12.6.6. SWOT Analysis
12.7. Eli Lilly and Company
12.7.1. Business Overview
12.7.2. Company Snapshot
12.7.3. Company Market Share Analysis
12.7.4. Company Product Portfolio
12.7.5. Recent Developments
12.7.6. SWOT Analysis
12.8. Amgen
12.8.1. Business Overview
12.8.2. Company Snapshot
12.8.3. Company Market Share Analysis
12.8.4. Company Product Portfolio
12.8.5. Recent Developments
12.8.6. SWOT Analysis
12.9. Swedish Orphan Biovitrum AB, 3SBio Inc.
12.9.1. Business Overview
12.9.2. Company Snapshot
12.9.3. Company Market Share Analysis
12.9.4. Company Product Portfolio
12.9.5. Recent Developments
12.9.6. SWOT Analysis
12.10. Samsung Bioepis Co., Ltd.
12.10.1. Business Overview
12.10.2. Company Snapshot
12.10.3. Company Market Share Analysis
12.10.4. Company Product Portfolio
12.10.5. Recent Developments
12.10.6. SWOT Analysis
12.11. 3SBio Inc.
12.11.1. Business Overview
12.11.2. Company Snapshot
12.11.3. Company Market Share Analysis
12.11.4. Company Product Portfolio
12.11.5. Recent Developments
12.11.6. SWOT Analysis
List of Table
1.Global Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
2.Global Biosimilar Drugs, Fc Fusion Protein Market, By Region, 2018–2030 (USD Billion)
3.Global Brands Drugs, Fc Fusion Protein Market, By Region, 2018–2030 (USD Billion)
4.Global Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
5.Global Eye Diseases Fc Fusion Protein Market, By Region, 2018–2030 (USD Billion)
6.Global Hemophilia Fc Fusion Protein Market, By Region, 2018–2030 (USD Billion)
7.Global Autoimmune Disease Fc Fusion Protein Market, By Region, 2018–2030 (USD Billion)
8.Global Diabetes Fc Fusion Protein Market, By Region, 2018–2030 (USD Billion)
9.Global Others Fc Fusion Protein Market, By Region, 2018–2030 (USD Billion)
10.Global Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
11.Global In vitro Fc Fusion Protein Market, By Region, 2018–2030 (USD Billion)
12.Global In vivo Fc Fusion Protein Market, By Region, 2018–2030 (USD Billion)
13.Global Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
14.Global Hospitals Fc Fusion Protein Market, By Region, 2018–2030 (USD Billion)
15.Global Ophthalmic or oculoplastic clinics Fc Fusion Protein Market, By Region, 2018–2030 (USD Billion)
16.Global Fc Fusion Protein Market, By Region, 2018–2030 (USD Billion)
17.North America Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
18.North America Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
19.North America Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
20.North America Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
21.U.S. Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
22.U.S. Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
23.U.S. Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
24.U.S. Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
25.Canada Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
26.Canada Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
27.Canada Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
28.Canada Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
29.Mexico Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
30.Mexico Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
31.Mexico Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
32.Mexico Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
33.Europe Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
34.Europe Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
35.Europe Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
36.Europe Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
37.Germany Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
38.Germany Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
39.Germany Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
40.Germany Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
41.France Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
42.France Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
43.France Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
44.France Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
45.U.K. Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
46.U.K. Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
47.U.K. Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
48.U.K. Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
49.Italy Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
50.Italy Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
51.Italy Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
52.Italy Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
53.Spain Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
54.Spain Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
55.Spain Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
56.Spain Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
57.Asia Pacific Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
58.Asia Pacific Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
59.Asia Pacific Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
60.Asia Pacific Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
61.Japan Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
62.Japan Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
63.Japan Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
64.Japan Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
65.China Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
66.China Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
67.China Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
68.China Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
69.India Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
70.India Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
71.India Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
72.India Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
73.South America Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
74.South America Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
75.South America Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
76.South America Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
77.Brazil Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
78.Brazil Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
79.Brazil Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
80.Brazil Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
81.Middle East and Africa Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
82.Middle East and Africa Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
83.Middle East and Africa Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
84.Middle East and Africa Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
85.UAE Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
86.UAE Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
87.UAE Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
88.UAE Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
89.South Africa Fc Fusion Protein Market, By Type, 2018–2030 (USD Billion)
90.South Africa Fc Fusion Protein Market, By Therapeutic Area, 2018–2030 (USD Billion)
91.South Africa Fc Fusion Protein Market, By Application, 2018–2030 (USD Billion)
92.South Africa Fc Fusion Protein Market, By End User, 2018–2030 (USD Billion)
List of Figures
1.Global Fc Fusion Protein Market Segmentation
2.Fc Fusion Protein Market: Research Methodology
3.Market Size Estimation Methodology: Bottom-Up Approach
4.Market Size Estimation Methodology: Top-Down Approach
5.Data Triangulation
6.Porter’s Five Forces Analysis
7.Value Chain Analysis
8.Global Fc Fusion Protein Market Attractiveness Analysis By Type
9.Global Fc Fusion Protein Market Attractiveness Analysis By Therapeutic Area
10.Global Fc Fusion Protein Market Attractiveness Analysis By Application
11.Global Fc Fusion Protein Market Attractiveness Analysis By End User
12.Global Fc Fusion Protein Market Attractiveness Analysis By Region
13.Global Fc Fusion Protein Market: Dynamics
14.Global Fc Fusion Protein Market Share By Type(2021 & 2030)
15.Global Fc Fusion Protein Market Share By Therapeutic Area(2021 & 2030)
16.Global Fc Fusion Protein Market Share By Application(2021 & 2030)
17.Global Fc Fusion Protein Market Share By End User(2021 & 2030)
18.Global Fc Fusion Protein Market Share by Regions (2021 & 2030)
19.Global Fc Fusion Protein Market Share by Company (2020)
This study forecasts revenue and volume growth at global, regional, and country levels from 2018 to 2030. The Brainy Insights has segmented the global Fc Fusion Protein market on the basis of below mentioned segments:
Global Fc Fusion Protein Market by Type:
Global Fc Fusion Protein Market by Therapeutic Area:
Global Fc Fusion Protein Market by Application:
Global Fc Fusion Protein Market by End User:
Global Fc Fusion Protein Market by Region:
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