The global Alagille Syndrome (ALGS) market was valued at USD 361.3 million in 2022 and is anticipated to grow at a CAGR of 6.3% from 2022 to 2030. The global Alagille Syndrome (ALGS) market is expected to reach USD 589.0 million by 2030. Europe is expected to grow the fastest during the forecast period.
An uncommon hereditary condition known as Alagille syndrome primarily affects the liver. The consequences subsequently spread to the body's other organs. One of the key factors driving the market's expansion is the rising incidence of cancer on a global scale. Other factors supporting the market's development include increasing spending on the construction of healthcare infrastructure and a rise in demand for novel cures and treatments. Other indirect factors that will generate profitable market growth prospects include increased paraganglioma incidences, increasing personal disposable income, and strategic collaboration and licensing agreements among the leading companies to develop treatments. However, the lack of knowledge caused by the rarity of the diseases and the unfavorable reimbursement situation in developing and underdeveloped nations would be a significant obstacle to the market's expansion. An increasing number of recalls would further hamper the market growth rate. For instance, Mirum Pharmaceuticals, Inc. stated in 2020 that it had submitted the first part of its rolling New Drug Application (NDA) for maralixibat to the U.S. Food and Drug Administration (FDA). Patients with Alagille syndrome are testing the effectiveness of maralixibat, a new, minimally absorbed, oral apical sodium-dependent bile acid transporter (ASBT) inhibitor, to treat cholestatic pruritus (ALGS). As a result, it is projected that the market will grow owing to the strong presence of medications for treating Alagille syndrome. The demand for Alagille syndrome treatments is anticipated to grow throughout the forecast period due to increasing awareness of the condition. However, it's believed that the market is constrained due to a lack of a healthcare budget.
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Focus on Developing New Drugs – Major market participants are concentrating on creating novel medication compounds for the treatment of Alagille syndrome, which are now undergoing clinical studies and are anticipated to gain US FDA approval soon. As a result, during the forecast period, the strong pipeline of medications for treating Alagille syndrome is expected to contribute considerably to market growth.
High Cost of treatment- The gap in health spending is yet to be covered in low and middle-income countries, as global health spending inequality has remained unaltered. For instance, high-income countries with only 16.3% of the world's population contribute 80% of global health spending, according to a 2015 WHO report titled "New Perspectives on Global Health Spending for Universal Health Coverage." However, just 20% of global health spending is spent in middle-income nations, home to 76.3% of the world's population. Low-income nations like Bangladesh, Afghanistan, and Burkina Faso, with approximately 500 million inhabitants, Burundi, and similar countries spent less than 1% of global health expenditures in 2015. Thus the high Cost of the treatment for Alagille syndrome is expected to hamper the market's growth.
Increased Funding– The global market for treating Alagille syndrome is anticipated to rise as financing, and investments for the treatment have increased. For instance, Mirum Pharmaceuticals Inc. announced on December 14, 2020, that Oberland Capital Management LLC would invest approximately US$ 210 million in its experimental liver disease medicine maralixibat. The amount is divided into US$ 200 million under a revenue-based finance arrangement and US$ 10 million under an equity investment agreement that the companies have agreed to. By December 31, 2020, Mirum Pharmaceuticals Inc. is anticipated to receive an initial US$ 60 million, which includes the US$ 10 million equity investment. After approval of the company's U.S. FDA NDA application for maralixibat, Oberland will disburse US$ 65 million.
Lack of Professionals- Low operating revenue opportunities for research and development skills and a lack of medical expertise in underdeveloped economies challenge the market's growth over the forecast period.
The regions analyzed for the market include North America, Europe, South America, Asia Pacific, the Middle East, and Africa. North America emerged as the largest global Alagille Syndrome (ALGS) market, with a 35.3% market revenue share in 2022.
North America currently dominates the Alagille Syndrome (ALGS) market. The Alagille Syndrome (ALGS) market in North America has been increasing owing to prominent market players such as Mirum Pharmaceuticals and Albireo Pharma, Inc. Furthermore, FDA approvals of therapeutics treatment for Alagille Syndrome (ALGS) add impetus to the market's growth in the region.
The Europe Alagille Syndrome (ALGS) treatment market is anticipated to grow significantly over the forecast period due to various programs launched by market participants to commercialize their goods. These programs are expected to fuel the market's expansion during the forecast period.
North America Region Alagille Syndrome (ALGS) Market Share in 2022 - 35.3%
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The symptoms segment is divided into liver problems, nutrition problems, heart problems, distinctive facial features, neurologic problems, and others. The liver problems segment dominated the market, with a market share of around 30% in 2022. Alagille syndrome is a rare hereditary condition that affects the liver, kidney, heart, eyes, and blood vessels, among other organs. However, in most cases, it affects the liver the most, adding impetus to the market's growth.
The drug segment is divided into ursodeoxycholic acid, cholestyramine, rifampin, naltrexone, and others. Over the forecast period, the ursodeoxycholic acid segment is expected to grow at the fastest CAGR of 6.9%. Ursodeoxycholic acid is one of the most commonly recommended pharmaceuticals for treating pruritus (itching) associated with Alagille syndrome, propelling the segment's growth.
The diagnosis segment is divided into blood tests, urinalysis, x-ray imaging, cardiology exams, slit-lamp exams, liver biopsy, genetic testing, prenatal DNA testing, and others. The urinalysis segment dominated the market with a market share of around 26.3% in 2022. In most cases, Alagille Syndrome (ALGS) diagnosis is made through urinalysis, which propels the segment's growth. Urinalysis may be used by doctors to rule out other medical conditions or to look for indications of renal issues associated with Alagille syndrome.
Report Description
Attribute | Description |
---|---|
Market Size | Revenue (USD Million) |
Market size value in 2022 | USD 361.3 Million |
Market size value in 2030 | USD 589.0 Million |
CAGR (2022 to 2030) | 6.3% |
Historical data | 2019-2020 |
Base Year | 2021 |
Forecast | 2022-2030 |
Regional Segments | North America, Asia Pacific, Europe, Latin America, Middle East and Africa |
Segments | Symptoms, Drugs, and Diagnosis |
As per The Brainy Insights, the size of the Alagille Syndrome (ALGS) market was valued at USD 361.3 million in 2022 to USD 589.0 million by 2030.
The global Alagille Syndrome (ALGS) market is growing at a CAGR of 6.3% during the forecast period 2022-2030.
North America emerged as the largest market for Alagille Syndrome (ALGS).
1. Introduction
1.1. Objectives of the Study
1.2. Market Definition
1.3. Research Scope
1.4. Currency
1.5. Key Target Audience
2. Research Methodology and Assumptions
3. Executive Summary
4. Premium Insights
4.1. Porter’s Five Forces Analysis
4.2. Value Chain Analysis
4.3. Top Investment Pockets
4.3.1. Market Attractiveness Analysis By Symptoms
4.3.2. Market Attractiveness Analysis By Drugs
4.3.3. Market Attractiveness Analysis By Diagnosis
4.3.4. Market Attractiveness Analysis By Region
4.4. Industry Trends
5. Market Dynamics
5.1. Market Evaluation
5.2. Drivers
5.2.1. Growing Increasing number of clinical studies and trials
5.3. Restraints
5.3.1. Stringent government regulations and restrictions
5.4. Opportunities
5.4.1. Rise as financing and investments
5.5. Challenges
5.5.1. Lack of medical expertise
1. Global Alagille Syndrome (ALGS) Market Analysis and Forecast, By Symptoms
1.1. Segment Overview
1.2. Liver Problems
1.3. Nutrition Problems
1.4. Heart Problems
1.5. Distinctive Facial Features
1.6. Neurologic Problems
1.7. Others
2. Global Alagille Syndrome (ALGS) Market Analysis and Forecast, By Drugs
2.1. Segment Overview
2.2. Ursodeoxycholic Acid
2.3. Cholestyramine
2.4. Rifampin
2.5. Naltrexone
2.6. Others
3. Global Alagille Syndrome (ALGS) Market Analysis and Forecast, By Diagnosis
3.1. Segment Overview
3.2. Blood Test
3.3. Urinalysis
3.4. X-ray Imaging
3.5. Cardiology Exam
3.6. Slit-lamp Exam
3.7. Liver Biopsy
3.8. Genetic Testing
3.9. Prenatal DNA testing
3.10. Others
4. Global Alagille Syndrome (ALGS) Market Analysis and Forecast, By Regional Analysis
4.1. Segment Overview
4.2. North America
4.2.1. U.S.
4.2.2. Canada
4.2.3. Mexico
4.3. Europe
4.3.1. Germany
4.3.2. France
4.3.3. U.K.
4.3.4. Italy
4.3.5. Spain
4.4. Asia-Pacific
4.4.1. Japan
4.4.2. China
4.4.3. India
4.5. South America
4.5.1. Brazil
4.6. Middle East and Africa
4.6.1. UAE
4.6.2. South Africa
5. Global Alagille Syndrome (ALGS) Market-Competitive Landscape
5.1. Overview
5.2. Market Share of Key Players in Global Alagille Syndrome (ALGS) Market
5.2.1. Global Company Market Share
5.2.2. North America Company Market Share
5.2.3. Europe Company Market Share
5.2.4. APAC Company Market Share
5.3. Competitive Situations and Trends
5.3.1. Product Launches and Developments
5.3.2. Partnerships, Collaborations, and Agreements
5.3.3. Mergers & Acquisitions
5.3.4. Expansions
6. Company Profiles
6.1. Albireo Pharma, Inc.
6.1.1. Business Overview
6.1.2. Company Snapshot
6.1.3. Company Market Share Analysis
6.1.4. Company Product Portfolio
6.1.5. Recent Developments
6.1.6. SWOT Analysis
6.2. Bioarray S.L.
6.2.1. Business Overview
6.2.2. Company Snapshot
6.2.3. Company Market Share Analysis
6.2.4. Company Product Portfolio
6.2.5. Recent Developments
6.2.6. SWOT Analysis
6.3. Mirum Pharmaceuticals
6.3.1. Business Overview
6.3.2. Company Snapshot
6.3.3. Company Market Share Analysis
6.3.4. Company Product Portfolio
6.3.5. Recent Developments
6.3.6. SWOT Analysis
6.4. Zydus Cadila
6.4.1. Business Overview
6.4.2. Company Snapshot
6.4.3. Company Market Share Analysis
6.4.4. Company Product Portfolio
6.4.5. Recent Developments
6.4.6. SWOT Analysis
6.5. ALLERGAN
6.5.1. Business Overview
6.5.2. Company Snapshot
6.5.3. Company Market Share Analysis
6.5.4. Company Product Portfolio
6.5.5. Recent Developments
6.5.6. SWOT Analysis
6.6. TEVA PHARMACEUTICAL INDUSTRIES LTD.
6.6.1. Business Overview
6.6.2. Company Snapshot
6.6.3. Company Market Share Analysis
6.6.4. Company Product Portfolio
6.6.5. Recent Developments
6.6.6. SWOT Analysis
6.7. Takeda Pharmaceutical Company Limited.
6.7.1. Business Overview
6.7.2. Company Snapshot
6.7.3. Company Market Share Analysis
6.7.4. Company Product Portfolio
6.7.5. Recent Developments
6.7.6. SWOT Analysis
6.8. Astrazeneca
6.8.1. Business Overview
6.8.2. Company Snapshot
6.8.3. Company Market Share Analysis
6.8.4. Company Product Portfolio
6.8.5. Recent Developments
6.8.6. SWOT Analysis
6.9. Lupin Pharmaceuticals, Inc.
6.9.1. Business Overview
6.9.2. Company Snapshot
6.9.3. Company Market Share Analysis
6.9.4. Company Product Portfolio
6.9.5. Recent Developments
6.9.6. SWOT Analysis
6.10. GlaxoSmithKline plc
6.10.1. Business Overview
6.10.2. Company Snapshot
6.10.3. Company Market Share Analysis
6.10.4. Company Product Portfolio
6.10.5. Recent Developments
6.10.6. SWOT Analysis
6.11. Endo International plc
6.11.1. Business Overview
6.11.2. Company Snapshot
6.11.3. Company Market Share Analysis
6.11.4. Company Product Portfolio
6.11.5. Recent Developments
6.11.6. SWOT Analysis
List of Table
1. Global Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
2. Global Liver Problems, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
3. Global Nutrition Problems, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
4. Global Heart Problems, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
5. Global Distinctive Facial Features, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
6. Global Neurologic Problems, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
7. Global Others, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
8. Global Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
9. Global Ursodeoxycholic Acid, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
10. Global Cholestyramine, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
11. Global Rifampin, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
12. Global Naltrexone, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
13. Global Others, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
14. Global Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
15. Global Blood Test, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
16. Global Urinalysis, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
17. Global X-ray Imaging, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
18. Global Cardiology Exam, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
19. Global Slit-lamp Exam, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
20. Global Liver Biopsy, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
21. Global Genetic Testing, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
22. Global Prenatal DNA testing, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
23. Global Others, Alagille Syndrome (ALGS) Market, By Region, 2019-2030 (USD Million)
24. North America Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
25. North America Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
26. North America Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
27. U.S. Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
28. U.S. Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
29. U.S. Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
30. Canada Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
31. Canada Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
32. Canada Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
33. Mexico Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
34. Mexico Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
35. Mexico Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
36. Europe Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
37. Europe Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
38. Europe Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
39. Germany Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
40. Germany Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
41. Germany Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
42. France Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
43. France Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
44. France Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
45. U.K. Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
46. U.K. Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
47. U.K. Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
48. Italy Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
49. Italy Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
50. Italy Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
51. Spain Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
52. Spain Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
53. Spain Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
54. Asia Pacific Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
55. Asia Pacific Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
56. Asia Pacific Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
57. Japan Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
58. Japan Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
59. Japan Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
60. China Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
61. China Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
62. China Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
63. India Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
64. India Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
65. India Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
66. South America Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
67. South America Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
68. South America Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
69. Brazil Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
70. Brazil Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
71. Brazil Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
72. Middle East and Africa Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
73. Middle East and Africa Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
74. Middle East and Africa Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
75. UAE Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
76. UAE Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
77. UAE Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
78. South Africa Alagille Syndrome (ALGS) Market, By Symptoms, 2019-2030 (USD Million)
79. South Africa Alagille Syndrome (ALGS) Market, By Drugs, 2019-2030 (USD Million)
80. South Africa Alagille Syndrome (ALGS) Market, By Diagnosis, 2019-2030 (USD Million)
List of Figures
1. Global Alagille Syndrome (ALGS) Market Segmentation
2. Global Alagille Syndrome (ALGS) Market: Research Methodology
3. Market Size Estimation Methodology: Bottom-Up Approach
4. Market Size Estimation Methodology: Top-Down Approach
5. Data Triangulation
6. Porter’s Five Forces Analysis
7. Value Chain Analysis
8. Global Alagille Syndrome (ALGS) Market Attractiveness Analysis By Symptoms
9. Global Alagille Syndrome (ALGS) Market Attractiveness Analysis By Drugs
10. Global Alagille Syndrome (ALGS) Market Attractiveness Analysis By Diagnosis
11. Global Alagille Syndrome (ALGS) Market Attractiveness Analysis By Region
12. Global Alagille Syndrome (ALGS) Market: Dynamics
13. Global Alagille Syndrome (ALGS) Market Share By Symptoms (2022 & 2030)
14. Global Alagille Syndrome (ALGS) Market Share By Drugs (2022 & 2030)
15. Global Alagille Syndrome (ALGS) Market Share By Diagnosis (2022 & 2030)
16. Global Alagille Syndrome (ALGS) Market Share By Regions (2022 & 2030)
17. Global Alagille Syndrome (ALGS) Market Share By Company (2021)
This study forecasts global, regional, and country revenue from 2019 to 2030. Brainy Insights has segmented the global Alagille Syndrome (ALGS) market based on the below-mentioned segments:
Global Alagille Syndrome (ALGS) Market by Symptoms:
Global Alagille Syndrome (ALGS) Market by Drugs:
Global Alagille Syndrome (ALGS) Market by Diagnosis:
Global Alagille Syndrome (ALGS) Market by Region:
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