CRISPR and Cas Gene Market

CRISPR and Cas Gene Market Share & Analysis – Industry Overview

Base Year: 2023 Historical Data: 2020-22
  • Report ID: TBI-14229
  • Published Date: Apr, 2024
  • Pages: 237
  • Category: Healthcare
  • Format: PDF
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Segment Analysis

Regional segmentation analysis

The regions analyzed for the market include North America, Europe, South America, Asia Pacific, the Middle East, and Africa. North America emerged as the most prominent global CRISPR and Cas Gene market, with a 40.17% market revenue share in 2023.

North America, particularly the United States, possesses advanced research infrastructure, including top-tier universities, research institutions, and biotechnology hubs. These institutions have been at the forefront of CRISPR-Cas research, contributing to significant advancements in the field and driving innovation. Furthermore, the availability of substantial funding from government agencies, private investors, and venture capitalists has fueled CRISPR-Cas research and development in North America. Initiatives like the NIH funding for genome editing research and grants from organizations like the National Science Foundation (NSF) have supported pioneering research projects and technology development. In addition, North America boasts a thriving biotechnology industry, with numerous biotech companies specializing in gene editing technologies. These companies, including industry leaders like CRISPR Therapeutics, Editas Medicine, and Intellia Therapeutics, are driving innovation in CRISPR-based therapeutics, diagnostics, and agricultural applications, contributing to the market's growth. Besides, North American institutions and companies have formed strategic partnerships and collaborations to advance CRISPR-Cas technologies. Collaborations between academia, industry, and government entities facilitate knowledge exchange, resource sharing, and technology transfer, accelerating the development and commercialization of CRISPR-based products and therapies.

North America Region CRISPR and Cas Gene Market Share in 2023 - 40.17%

 

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Product Segment Analysis

The product segment is divided into vector-based cas, DNA-free cas and others. The vector-based cas segment dominated the market, with a share of around 44.76% in 2023. Vector-based CRISPR-Cas systems, such as viral vectors (e.g., lentiviral, adenoviral, adeno-associated viral vectors) or non-viral vectors (e.g., plasmids), offer efficient delivery of CRISPR-Cas components into target cells or tissues. These vectors can effectively transport Cas proteins, guide RNAs, and donor DNA templates to facilitate precise genome editing. Furthermore, viral vectors, in particular, exhibit high transduction efficiency, allowing for robust and widespread delivery of CRISPR-Cas components into various cell types, including hard-to-transfect cells and primary cells. This high efficiency is essential for achieving therapeutic levels of gene editing in clinical applications. Additionally, vector-based CRISPR-Cas systems can mediate the stable integration of transgenes or gene-editing machinery into the host genome, leading to long-lasting gene expression and sustained editing activity. This feature is advantageous for applications requiring persistent gene modification, such as gene therapy and cellular reprogramming.

Service Segment Analysis

The service segment is classified into DNA synthesis, cell line engineering, gRNA design and microbial gene editing. The microbial gene editing segment dominated the market, with a share of around 42.61% in 2023. CRISPR-Cas systems were initially discovered and characterized in microbial organisms, particularly bacteria and archaea. The natural function of CRISPR-Cas systems in microbial defence against viruses and foreign DNA provided the foundation for developing CRISPR-based gene editing tools. In addition, microbial CRISPR-Cas systems exhibit remarkable versatility and adaptability, with diverse types and subtypes identified across different microbial species. This diversity allows researchers to select CRISPR-Cas variants with desirable properties, such as high specificity, efficiency, or targeting range, for specific gene editing applications. Moreover, microbial CRISPR-Cas systems are relatively simple and accessible compared to alternative gene editing technologies. The components required for microbial gene editing, including Cas proteins and guide RNAs, are readily available, easy to manipulate, and cost-effective to produce, enabling widespread adoption and experimentation in research laboratories.

Application Segment Analysis

The application segment includes genome engineering, disease model studies, functional genomics, epigenetics and others. The genome engineering segment dominated the market, with a share of around 40.13% in 2023. CRISPR-Cas gene editing offers unparalleled precision and versatility in genome engineering. The ability to precisely target specific DNA sequences for modification allows researchers to edit genes with high accuracy, enabling various applications in basic research, biotechnology, and therapeutic development. Besides, CRISPR-Cas systems provide efficient and scalable tools for genome engineering. The simplicity of CRISPR-Cas technology allows for rapid and cost-effective editing of genes in various organisms and cell types, making it accessible to a wide range of researchers and industries. Most importantly, genome engineering using CRISPR-Cas technology has many applications across multiple fields, including agriculture, medicine, biotechnology, and basic research. CRISPR-based gene editing enables precise modification of genes to improve crop traits, develop novel therapeutics, create genetically modified organisms, and study gene function.

End User Segment Analysis

The end user segment is split into academics & government research institutes, biotechnology & pharmaceutical companies, and contract research organizations (CROs). The biotechnology & pharmaceutical companies segment dominated the market, with a share of around 50.37% in 2023. Biotechnology and pharmaceutical companies possess extensive research and development capabilities, including molecular biology, genomics, and drug discovery expertise. These companies have the resources and infrastructure to conduct comprehensive research on CRISPR-Cas gene editing, driving innovation and technological advancements. Furthermore, biotech and pharmaceutical firms have invested heavily in developing and commercializing CRISPR-Cas gene editing technologies. These investments support the discovery of novel CRISPR-based applications, the optimization of gene editing tools, and the translation of research findings into therapeutic products and services. Moreover, biotechnology and pharmaceutical companies are focused on developing CRISPR-based therapeutics for treating various diseases, including genetic disorders, cancer, infectious diseases, and rare conditions. These companies leverage CRISPR-Cas gene editing to develop innovative therapies with the potential to address unmet medical needs and improve patient outcomes.

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This study forecasts revenue at global, regional, and country levels from 2020 to 2033. The Brainy Insights has segmented the global CRISPR and Cas Gene market based on below-mentioned segments:

Global CRISPR and Cas Gene Market by Product:

  • Vector-based Cas    
  • DNA-free Cas
  • Others

Global CRISPR and Cas Gene Market by Service:

  • DNA Synthesis
  • Cell Line Engineering
  • gRNA design
  • Microbial Gene Editing 

Global CRISPR and Cas Gene Market by Application:

  • Genome Engineering      
  • Disease Model Studies
  • Functional Genomics
  • Epigenetics
  • Others

Global CRISPR and Cas Gene Market by End User:

  • Academics & Government Research Institutes
  • Biotechnology & Pharmaceutical Companies
  • Contract Research Organizations (CROs)

Global CRISPR and Cas Gene Market by Region:

  • North America
    • U.S.
    • Canada
    • Mexico
  • Europe
    • Germany
    • France
    • U.K.
    • Italy
    • Spain
  • Asia-Pacific
    • Japan
    • China
    • India
  • South America
    • Brazil
  • Middle East and Africa  
    • UAE
    • South Africa

Methodology

Research has its special purpose to undertake marketing efficiently. In this competitive scenario, businesses need information across all industry verticals; the information about customer wants, market demand, competition, industry trends, distribution channels etc. This information needs to be updated regularly because businesses operate in a dynamic environment. Our organization, The Brainy Insights incorporates scientific and systematic research procedures in order to get proper market insights and industry analysis for overall business success. The analysis consists of studying the market from a miniscule level wherein we implement statistical tools which helps us in examining the data with accuracy and precision. 

Our research reports feature both; quantitative and qualitative aspects for any market. Qualitative information for any market research process are fundamental because they reveal the customer needs and wants, usage and consumption for any product/service related to a specific industry. This in turn aids the marketers/investors in knowing certain perceptions of the customers. Qualitative research can enlighten about the different product concepts and designs along with unique service offering that in turn, helps define marketing problems and generate opportunities. On the other hand, quantitative research engages with the data collection process through interviews, e-mail interactions, surveys and pilot studies. Quantitative aspects for the market research are useful to validate the hypotheses generated during qualitative research method, explore empirical patterns in the data with the help of statistical tools, and finally make the market estimations.

The Brainy Insights offers comprehensive research and analysis, based on a wide assortment of factual insights gained through interviews with CXOs and global experts and secondary data from reliable sources. Our analysts and industry specialist assume vital roles in building up statistical tools and analysis models, which are used to analyse the data and arrive at accurate insights with exceedingly informative research discoveries. The data provided by our organization have proven precious to a diverse range of companies, facilitating them to address issues such as determining which products/services are the most appealing, whether or not customers use the product in the manner anticipated, the purchasing intentions of the market and many others.

Our research methodology encompasses an idyllic combination of primary and secondary initiatives. Key phases involved in this process are listed below:

MARKET RESEARCH PROCESS

Data Procurement:

The phase involves the gathering and collecting of market data and its related information with the help of different sources & research procedures.

The data procurement stage involves in data gathering and collecting through various data sources.

This stage involves in extensive research. These data sources includes:

Purchased Database: Purchased databases play a crucial role in estimating the market sizes irrespective of the domain. Our purchased database includes:

  • The organizational databases such as D&B Hoovers, and Bloomberg that helps us to identify the competitive scenario of the key market players/organizations along with the financial information.
  • Industry/Market databases such as Statista, and Factiva provides market/industry insights and deduce certain formulations. 
  • We also have contractual agreements with various reputed data providers and third party vendors who provide information which are not limited to:
    • Import & Export Data
    • Business Trade Information
    • Usage rates of a particular product/service on certain demographics mainly focusing on the unmet prerequisites

Primary Research: The Brainy Insights interacts with leading companies and experts of the concerned domain to develop the analyst team’s market understanding and expertise. It improves and substantiates every single data presented in the market reports. Primary research mainly involves in telephonic interviews, E-mail interactions and face-to-face interviews with the raw material providers, manufacturers/producers, distributors, & independent consultants. The interviews that we conduct provides valuable data on market size and industry growth trends prevailing in the market. Our organization also conducts surveys with the various industry experts in order to gain overall insights of the industry/market. For instance, in healthcare industry we conduct surveys with the pharmacists, doctors, surgeons and nurses in order to gain insights and key information of a medical product/device/equipment which the customers are going to usage. Surveys are conducted in the form of questionnaire designed by our own analyst team. Surveys plays an important role in primary research because surveys helps us to identify the key target audiences of the market. Additionally, surveys helps to identify the key target audience engaged with the market. Our survey team conducts the survey by targeting the key audience, thus gaining insights from them. Based on the perspectives of the customers, this information is utilized to formulate market strategies. Moreover, market surveys helps us to understand the current competitive situation of the industry. To be precise, our survey process typically involve with the 360 analysis of the market. This analytical process begins by identifying the prospective customers for a product or service related to the market/industry to obtain data on how a product/service could fit into customers’ lives.

Secondary Research: The secondary data sources includes information published by the on-profit organizations such as World bank, WHO, company fillings, investor presentations, annual reports, national government documents, statistical databases, blogs, articles, white papers and others. From the annual report, we analyse a company’s revenue to understand the key segment and market share of that organization in a particular region. We analyse the company websites and adopt the product mapping technique which is important for deriving the segment revenue. In the product mapping method, we select and categorize the products offered by the companies catering to domain specific market, deduce the product revenue for each of the companies so as to get overall estimation of the market size. We also source data and analyses trends based on information received from supply side and demand side intermediaries in the value chain. The supply side denotes the data gathered from supplier, distributor, wholesaler and the demand side illustrates the data gathered from the end customers for respective market domain.

The supply side for a domain specific market is analysed by:

  • Estimating and projecting penetration rates through analysing product attributes, availability of internal and external substitutes, followed by pricing analysis of the product.
  • Experiential assessment of year-on-year sales of the product by conducting interviews.

The demand side for the market is estimated through:

  • Evaluating the penetration level and usage rates of the product.
  • Referring to the historical data to determine the growth rate and evaluate the industry trends

In-house Library: Apart from these third-party sources, we have our in-house library of qualitative and quantitative information. Our in-house database includes market data for various industry and domains. These data are updated on regular basis as per the changing market scenario. Our library includes, historic databases, internal audit reports and archives.

Sometimes there are instances where there is no metadata or raw data available for any domain specific market. For those cases, we use our expertise to forecast and estimate the market size in order to generate comprehensive data sets. Our analyst team adopt a robust research technique in order to produce the estimates:

  • Applying demographic along with psychographic segmentation for market evaluation
  • Determining the Micro and Macro-economic indicators for each region 
  • Examining the industry indicators prevailing in the market. 

Data Synthesis: This stage involves the analysis & mapping of all the information obtained from the previous step. It also involves in scrutinizing the data for any discrepancy observed while data gathering related to the market. The data is collected with consideration to the heterogeneity of sources. Robust scientific techniques are in place for synthesizing disparate data sets and provide the essential contextual information that can orient market strategies. The Brainy Insights has extensive experience in data synthesis where the data passes through various stages:

  • Data Screening: Data screening is the process of scrutinising data/information collected from primary research for errors and amending those collected data before data integration method. The screening involves in examining raw data, identifying errors and dealing with missing data. The purpose of the data screening is to ensure data is correctly entered or not. The Brainy Insights employs objective and systematic data screening grades involving repeated cycles of quality checks, screening and suspect analysis.
  • Data Integration: Integrating multiple data streams is necessary to produce research studies that provide in-depth picture to the clients. These data streams come from multiple research studies and our in house database. After screening of the data, our analysts conduct creative integration of data sets, optimizing connections between integrated surveys and syndicated data sources. There are mainly 2 research approaches that we follow in order to integrate our data; top down approach and bottom up approach.

Market Deduction & Formulation: The final stage comprises of assigning data points at appropriate market spaces so as to deduce feasible conclusions. Analyst perspective & subject matter expert based holistic form of market sizing coupled with industry analysis also plays a crucial role in this stage.

This stage involves in finalization of the market size and numbers that we have collected from data integration step. With data interpolation, it is made sure that there is no gap in the market data. Successful trend analysis is done by our analysts using extrapolation techniques, which provide the best possible forecasts for the market.

Data Validation & Market Feedback: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helps us finalize data-points to be used for final calculations.

The Brainy Insights interacts with leading companies and experts of the concerned domain to develop the analyst team’s market understanding and expertise. It improves and substantiates every single data presented in the market reports. The data validation interview and discussion panels are typically composed of the most experienced industry members. The participants include, however, are not limited to:

  • CXOs and VPs of leading companies’ specific to sector
  • Purchasing managers, technical personnel, end-users
  • Key opinion leaders such as investment bankers, and industry consultants

Moreover, we always validate our data and findings through primary respondents from all the major regions we are working on.

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